Article
Discovery of TCR-like antibodies to the KRAS G12D neoantigen via in silico-in vitro workflow.
Molecular therapy : the journal of the American Society of Gene Therapy - 2 Sept 2026
Ahn SangPhil, Oh Tae-Sung, Suh Seonghyuk, Jeon Joon-Young, Lah Sangjoon, Ryu Kyeongmin, Choi Sanghyeon, Kim Hyeonkyeong, Lee Eun Gyo, Lee Hyejin, Lee JooYeon, Kim Yoonji, Kim Sanggil, Park So Ra, Yoo Hojin, Choi So-Young, Lee Joo Eon, Kim Dong-Kyun, Ku Bo Mi, Jung Wooram, Ahn Myung-Ju, Jung Jae U, Kim Yong-Sung, Oh Byung-Ha, Jeong Bo-Seong
Abstract excerpt
Antibodies that recognize peptide-loaded class I major histocompatibility complex (MHC) molecules could enable therapeutic targeting of intracellular oncogenic proteins, yet their discovery has been hampered by the small size of peptide antigens and the need for allele-specific recognition. Here, we describe an integrated in silico-in vitro workflow for generating high-affinity, selective antibodies to Kirsten...
Read the complete abstract on PubMedTopics
- Humans
- Proto-Oncogene Proteins p21(ras)
- Receptors, Antigen, T-Cell
- Antigens, Neoplasm