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Article

Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens.

eLife - 10 Dec 2024

Torelli Francesca, da Fonseca Diogo M, Butterworth Simon W, Young Joanna C, Treeck Moritz

Abstract excerpt

Toxoplasma gondii is an intracellular parasite that subverts host cell functions via secreted virulence factors. Up to 70% of parasite-controlled changes in the host transcriptome rely on the MYR1 protein, which is required for the translocation of secreted proteins into the host cell. Mice infected with MYR1 knock-out (KO) strains survive infection, supporting a paramount function of MYR1-dependent secreted...

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Identifiers

PMID: 39654402
DOI: 10.7554/eLife.102592
PMCID: PMC11630813

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Paracrine rescue of MYR1-deficient Toxoplasma gondii mutants reveals limitations of pooled in vivo CRISPR screens.PMID 39654402Read ↗

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