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A genome-wide loss-of-function screen identifies <i>Toxoplasma gondii</i> genes that determine fitness in interferon gamma-activated murine macrophages

2019-12-06

Abstract excerpt

<h4>ABSTRACT</h4> Macrophages play an essential role in the early immune response against Toxoplasma and are the cell type preferentially infected by the parasite in vivo . Interferon gamma (IFNγ) elicits a variety of anti- Toxoplasma activities in macrophages. Using a genome-wide CRISPR screen we identified ∼130 Toxoplasma genes that determine parasite fitness in naїve macrophages and ∼466 genes that determi...

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Literature Corpus work
9e1d1bed-5580-5697-8684-c15f9427a829
DOI
10.1101/867705
Open publication

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A genome-wide loss-of-function screen identifies <i>Toxoplasma gondii</i> genes that determine fitness in interferon gamma-activated murine macrophagesDOI 10.1101/867705
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