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Article

Toxoplasma gondii effector TgIST blocks type I interferon signaling to promote infection

14 Aug 2019

Abstract excerpt

In contrast to the importance of type II interferon-γ (IFN-γ) in control of toxoplasmosis, the role of type I IFN is less clear. We demonstrate here that TgIST, a secreted effector previously implicated in blocking type II IFN-γ signaling, also blocked IFN-β responses by inhibiting STAT1/STAT2-mediated transcription in infected cells. Consistent with a role for type I IFN in cell intrinsic control, ∆ Tgis t...

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PMID: 31413201
DOI: 10.1073/pnas.1904637116

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