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Genome-wide plasma DNA methylation features of metastatic prostate cancer

9 Mar 2020

Abstract excerpt

Tumor DNA circulates in the plasma of cancer patients admixed with DNA from noncancerous cells. The genomic landscape of plasma DNA has been characterized in metastatic castration-resistant prostate cancer (mCRPC) but the plasma methylome has not been extensively explored. Here, we performed next-generation sequencing (NGS) on plasma DNA with and without bisulfite treatment from mCRPC patients receiving either...

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PMID: 32149736
DOI: 10.1172/jci130887

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