TLR7 rs179008 (A/T) and TLR7 rs3853839 (C/G) polymorphisms are associated with variations in IFN-α levels in HTLV-1 infection.

doi:10.3389/fimmu.2024.1462352

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TLR7 rs179008 (A/T) and TLR7 rs3853839 (C/G) polymorphisms are associated with variations in IFN-α levels in HTLV-1 infection.

Frontiers in immunology - 1 Jan 2024

Santana Emmanuelle Giuliana Mendes, Ferreira Fabiane Dos Santos, Brito Wandrey Roberto Dos Santos, Lopes Felipe Teixeira, de Lima Aline Cecy Rocha, Neto Gabriel Dos Santos Pereira, Amoras Ednelza da Silva Graça, Lima Sandra Souza, da Costa Carlos Araujo, Souza Maísa Silva, Ishak Ricardo, Cayres-Vallinoto Izaura Maria Vieira, Vallinoto Antonio Carlos Rosário, Queiroz Maria Alice Freitas

Abstract excerpt

Introduction: TLR7 detects the presence of single-stranded RNA (ssRNA) viruses, including human T-lymphotropic virus 1 (HTLV-1), and triggers antiviral and inflammatory responses that are responsible for infection control. Genetic variations in the TLR7 gene may alter cytokine production and influence the course of HTLV-1 infection. In the present study, the associations of TLR7 gene polymorphisms with...

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PMID: 39650644
DOI: 10.3389/fimmu.2024.1462352
PMCID: PMC11621001

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