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Article

A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression.

AIDS (London, England) - 28 Jan 2009

Oh Djin-Ye, Baumann Konstantin, Hamouda Osamah, Eckert Jana K, Neumann Konrad, Kücherer Claudia, Bartmeyer Barbara, Poggensee Gabriele, Oh Nari, Pruss Axel, Jessen Heiko, Schumann Ralf R

Abstract excerpt

OBJECTIVES: Toll-like receptors (TLRs) play an important role in the innate immune response to pathogens. TLR7 recognizes RNA of various viruses including HIV. The objective of this study was to examine the influence of individual genetic variations of TLR7 on the susceptibility to and progression of HIV disease. METHOD: We genotyped a population of 734 HIV-positive adults and 545 healthy controls for three TLR7...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19114863
DOI: 10.1097/QAD.0b013e32831fb540

Genes

TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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