Article
Association of single-nucleotide polymorphisms in TLR7 (Gln11Leu) and TLR9 (1635A/G) with a higher CD4T cell count during HIV infection.
Immunology letters - 1 Jul 2014
Said E A, Al-Yafei F, Zadjali F, Hasson S S, Al-Balushi M S, Al-Mahruqi S, Koh C Y, Al-Naamani K, Al-Busaidi J Z, Idris M A, Balkhair A, Al-Jabri A A
Abstract excerpt
BACKGROUND: Toll-like receptors (TLRs) are essential elements of the innate immune response to different infections including HIV-1 infection. The single-nucleotide polymorphisms (SNPs) in TLRs have been associated with CD4T cell count and HIV disease progression. The TLR7 (Gln11Leu) SNP was shown to be associated with a rapid decline of CD4T cell count. A relation between TLR9 (1635A/G) SNP and CD4T cells count...
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