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Article

A potential bimodal interplay between heme and complement factor H 402H in the deregulation of the complement alternative pathway by SARS-CoV-2.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Dec 2024

Tsiftsoglou Stefanos A, Gavriilaki Eleni

Abstract excerpt

The recent discovery that the trimeric SARS-CoV-2 spike S glycoprotein carries heme within an NTD domain pocket of the S1 subunits, suggested that this virus may be cleverly utilizing heme, in addition to the S1 RBD domains, for invading target cells carrying a specific entry receptor like ACE2, TMEM106B and others. Studies during the COVID-19 pandemic revealed that the infectivity of this virus depends on cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39643072
DOI: 10.1016/j.meegid.2024.105698

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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