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New functional and structural insights from updated mutational databases for complement factor H, Factor I, membrane cofactor protein and C3

5 Sept 2014

Abstract excerpt

aHUS (atypical haemolytic uraemic syndrome), AMD (age-related macular degeneration) and other diseases are associated with defective AP (alternative pathway) regulation. CFH (complement factor H), CFI (complement factor I), MCP (membrane cofactor protein) and C3 exhibited the most disease-associated genetic alterations in the AP. Our interactive structural database for these was updated with a total of 324...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25188723
DOI: 10.1042/bsr20140117

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