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Article

Ovulation sources ROS to confer mutagenic activities on the TP53 gene in the fallopian tube epithelium.

Neoplasia (New York, N.Y.) - 1 Jan 2025

Subramani Kanchana, Huang Hsuan-Shun, Chen Pao-Chu, Ding Dah-Ching, Chu Tang-Yuan

Abstract excerpt

INTRODUCTION: Epidemiological studies have implicated ovulation as a risk factor for ovarian high-grade serous carcinoma (HGSC) at the initiation stage. Precancerous lesions of HGSC commonly exhibit TP53 mutations attributed to DNA deamination and are frequently localized in the fallopian tube epithelium (FTE), a site regularly exposed to ovulatory follicular fluid (FF). This study aimed to assess the mutagenic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39637685
DOI: 10.1016/j.neo.2024.101085
PMCID: PMC11664131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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