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Article

Tubal ligation exacerbates ovulation-driven TP53 mutagenesis and p53 signatures by depleting protective menstrual hemoglobin.

The Journal of pathology - 1 Jul 2026

Subramani Kanchana, Su Cheng-Chuan, Wang Jen-Hung, Huang Hsuan-Shun, Hsu Chun-Shuo, Chen Pao-Chu, Chu Tang-Yuan

Abstract excerpt

The fallopian tube epithelium (FTE) is the primary tissue of origin for ovarian high-grade serous carcinoma (HGSC), with ovulation implicated as a key risk factor. TP53 mutations, a hallmark of HGSC and its precursor lesions, such as p53 signature, are predominantly CG>TA substitutions attributed to cytidine deamination. We previously demonstrated that ovulatory follicular fluid (FF) released reactive oxygen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42052633
DOI: 10.1002/path.70064

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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