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Mutant p53 disrupts antioxidant defense in fallopian tube epithelium via GSTAs suppression: A pathway to serous tubal carcinogenesis.

Free radical biology & medicine - 1 Feb 2026

Burnett Destiny B, St-Hilaire Sandy, Dodds Leah, Nelson Omar, Ravix Jovanka, Sowamber Ramlogan, Sealy Ashlee J, Paudel Iru, Morales Osmaray, Xu Xiang-Xi, Schlumbrecht Matthew, Shaw Patricia A, Smith Elizabeth R, George Sophia H L

Abstract excerpt

High grade serous ovarian cancer (HGSOC) is the most common and aggressive type of epithelial ovarian cancer. The fimbria of the fallopian tube is the likely site of origin based on the presence of distinct precancerous lesions with TP53 signatures known clinically as serous tubal intraepithelial carcinoma (STICs) detected in this region in individuals at genetically high risk or with HGSOC. Previously we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41275930
DOI: 10.1016/j.freeradbiomed.2025.11.027

Genes

GSTA2
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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