Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanisms of High-Grade Serous Carcinogenesis in the Fallopian Tube and Ovary: Current Hypotheses, Etiologic Factors, and Molecular Alterations

23 Apr 2021

Abstract excerpt

Ovarian high-grade serous carcinomas (HGSCs) are a heterogeneous group of diseases. They include fallopian-tube-epithelium (FTE)-derived and ovarian-surface-epithelium (OSE)-derived tumors. The risk/protective factors suggest that the etiology of HGSCs is multifactorial. Inflammation caused by ovulation and retrograde bleeding may play a major role. HGSCs are among the most genetically altered cancers, and TP53...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ovarian cancer diagnosis and treatment
Share to PARP inhibition in cancer therapy
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33922503
DOI: 10.3390/ijms22094409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanisms of High-Grade Serous Carcinogenesis in the Fallopian Tube and Ovary: Current Hypotheses, Etiologic Factors, and Molecular AlterationsPMID 33922503Read ↗

Sequential molecular changes and dynamic oxidative stress in high-grade serous ovarian carcinogenesis.Semantic proximity Read ↗

Pathogenesis and heterogeneity of ovarian cancerSemantic proximity Read ↗

Exploring the Role of Fallopian Ciliated Cells in the Pathogenesis of High-Grade Serous Ovarian Cancer.Semantic proximity Read ↗

High-Grade Serous Ovarian Cancer—A Risk Factor Puzzle and Screening FugitiveSemantic proximity Read ↗

Rete Ovarii Epithelial Cells as an Unappreciated Cell of Origin for Pelvic and Ovarian High-Grade Serous CarcinomaSemantic proximity Read ↗

Lessons from BRCA: the tubal fimbria emerges as an origin for pelvic serous cancer.Semantic proximity Read ↗

The molecular fingerprint of high grade serous ovarian cancer reflects its fallopian tube origin.Semantic proximity Read ↗

Cellular models of development of ovarian high‐grade serous carcinoma: A review of cell of origin and mechanisms of carcinogenesisSemantic proximity Read ↗

Replication stress and defective checkpoints make fallopian tube epithelial cells putative drivers of high-grade serous ovarian cancerSemantic proximity Read ↗

Ovarian Cancer: The Fallopian Tube as the Site of Origin and Opportunities for PreventionSemantic proximity Read ↗

Ovarian carcinomas: at least five different diseases with distinct histological features and molecular genetics.Semantic proximity Read ↗

Histologic, molecular, and cytogenetic features of ovarian cancers: implications for diagnosis and treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.