A percolation theory analysis of continuous functional paths in protein sequence space affirms previous insights on the optimization of proteins for adaptability.

Abstract excerpt

A key question in protein evolution and protein engineering is the prevalence of evolutionary paths between distinct proteins. An evolutionary path corresponds to a continuous path of functional sequences in sequence space leading from one protein to another. Natural selection could direct a mutating coding region in DNA along a continuous functional path (CFP), so a new protein could arise far more easily than...

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