Article
Physical origins of protein superfamilies.
Journal of molecular biology - 7 Apr 2006
Zeldovich Konstantin B, Berezovsky Igor N, Shakhnovich Eugene I
Abstract excerpt
In this work, we discovered a fundamental connection between selection for protein stability and emergence of preferred structures of proteins. Using a standard exact three-dimensional lattice model we evolve sequences starting from random ones and determine the exact native structure after each...
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