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Article

Protein stability imposes limits on organism complexity and speed of molecular evolution.

Proceedings of the National Academy of Sciences of the United States of America - 9 Oct 2007

Zeldovich Konstantin B, Chen Peiqiu, Shakhnovich Eugene I

Abstract excerpt

Classical population genetics a priori assigns fitness to alleles without considering molecular or functional properties of proteins that these alleles encode. Here we study population dynamics in a model where fitness can be inferred from physical properties of proteins under a physiological assumption that loss of stability of any protein encoded by an essential gene confers a lethal phenotype. Accumulation of...

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Identifiers

PMID: 17913881
DOI: 10.1073/pnas.0705366104
PMCID: PMC2042177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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