Article
Green function of correlated genes in a minimal mechanical model of protein evolution.
Proceedings of the National Academy of Sciences of the United States of America - 15 May 2018
Dutta Sandipan, Eckmann Jean-Pierre, Libchaber Albert, Tlusty Tsvi
Abstract excerpt
The function of proteins arises from cooperative interactions and rearrangements of their amino acids, which exhibit large-scale dynamical modes. Long-range correlations have also been revealed in protein sequences, and this has motivated the search for physical links between the observed genetic and dynamic cooperativity. We outline here a simplified theory of protein, which relates sequence correlations to...
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