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Article

Protein-coding mutation in Adcy3 increases adiposity and alters emotional behaviors sex-dependently in rats.

Obesity (Silver Spring, Md.) - 1 Jan 2025

Fitzpatrick Mackenzie K, Szalanczy Alexandria, Beeson Angela, Vora Anusha, Scott Christina, Grzybowski Michael, Klotz Jason, Der Nataley, Chen Rong, Geurts Aron M, Solberg Woods Leah C

Abstract excerpt

OBJECTIVE: Adenylate cyclase 3 (Adcy3) has been linked to both obesity and major depressive disorder. We identified a protein-coding variant in the transmembrane (TM) helix of Adcy3 in rats; similar obesity variants have been identified in humans. This study investigates the role of a TM variant in adiposity and behavior. METHODS: We mutated the TM domain of Adcy3 (Adcy3mut/mut) and created a heterozygous...

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Share to Adenylyl Cyclases
Share to Adiposity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Behavior, Animal

Share to Cyclic AMP Response Element-Binding Protein

Share to Diet, High-Fat

Share to Emotions

Share to Energy Metabolism

Share to Rats, Inbred WKY

Source

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Identifiers

PMID: 39632398
DOI: 10.1002/oby.24178
PMCID: PMC12247540

Genes

ADCY3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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