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Article

A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity.

PloS one - 1 Jan 2014

Pitman Jeffrey L, Wheeler Matthew C, Lloyd David J, Walker John R, Glynne Richard J, Gekakis Nicholas

Abstract excerpt

In a screen for genes that affect the metabolic response to high-fat diet (HFD), we selected one line of N-ethyl-N-nitrosourea (ENU)-mutagenized mice, Jll, with dominantly inherited resistance to diet-induced obesity (DIO). Mutant animals had dramatically reduced body weight and fat mass, and low basal insulin and glucose levels relative to unaffected controls. Both white adipose tissue (WAT) and brown adipose...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25329148
DOI: 10.1371/journal.pone.0110226
PMCID: PMC4199629

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