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Article

Molecular modelling of novel ADCY3 variant predicts a molecular target for tackling obesity.

International journal of molecular medicine - 1 Jan 2022

Toumba Meropi, Fanis Pavlos, Vlachakis Dimitrios, Neocleous Vassos, Phylactou Leonidas A, Skordis Nicos, Mantzoros Christos S, Pantelidou Maria

Abstract excerpt

Severe early‑onset obesity is mainly attributed to single gene variations of the hypothalamic leptin‑melanocortin system, which is critical for controlling the balance between appetite and energy expenditure. Adenylate cyclase 3 (ADCY3), a transmembrane enzyme localized in primary neuronal cilia, is a key genetic candidate, which appears to have an essential role in regulating body weight. The present study aimed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34821371
DOI: 10.3892/ijmm.2021.5065
PMCID: PMC8651229

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