Article
A Mutation in the Transmembrane Domain of Adenylate Cyclase 3 Impairs Enzymatic Function to Cause Sex-Specific Depression- and Anxiety-Like Behaviors and Food Seeking in a Rat Model.
Genes, brain, and behavior - 1 Jun 2025
Fitzpatrick Mackenzie K, Dyson Christina, Beeson Angela, Adrian Leighelle, Marrs Glen, Grzybowski Michael, Klotz Jason, Geurts Aron M, Chen Rong, Weiner Jeffrey L, Solberg Woods Leah C
Abstract excerpt
We have previously demonstrated that a transmembrane domain mutation in Adenylate cyclase 3 (Adcy3) causes increased adiposity and negative emotion-like behaviors in a rat model. We set out to replicate and expand upon our previous study by conducting comprehensive behavioral testing, and we also investigated the molecular changes that result from this mutation. Rats with a mutation in the second transmembrane...
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