Article

Loss-of-function mutations in ADCY3 cause monogenic severe obesity

2018-09-11

Abstract excerpt

Study of monogenic forms of obesity has demonstrated the pivotal role of the central leptin-melanocortin pathway in controlling energy balance, appetite and body weight 1 .The majority of loss-of-function mutations (mostly recessive or co-dominant) have been identified in genes that are directly involved in leptin-melanocortin signaling.These genes, however, only explain obesity in < 5% of cases, predominantly fro...

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Diet and metabolism studies

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Literature Corpus work: 5c900659-f58a-569e-b8bf-d14177f17de6
DOI: 10.1530/ey.15.11.5

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