Article

<i>ADCY3</i> Ser107Pro links difficulty awakening in the morning to adiposity through circadian regulation of adipose thermogenesis

2025-07-30

Abstract excerpt

<h4>SUMMARY</h4> Modern lifestyles often disturb circadian rhythms, yet the genetic circuits that convert this stress into metabolic dysfunction remain poorly defined. Here, we identify a missense variant in ADCY3 (rs11676272; Ser107Pro) as a pleiotropic regulator of circadian preference and adiposity. Using genome-wide pleiotropy analysis in ∼480,000 UK Biobank participants, we show that the G risk allele (Pro1...

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Identifiers and source

Literature Corpus work: 8720e1c5-cdfe-5544-a0b1-3bfb60d2a270
DOI: 10.1101/2025.07.28.667339

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