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Article

Impact of CD40 (rs1883832) and CD40L (rs1126535) gene variants on laryngeal cancer susceptibility and their association with serum biomarker levels of sCD40 and sCD40L.

PloS one - 1 Jan 2024

Gümüş Alper, Sönmez Dilara, Demirkol Şeyda, Tolgahan Hakan Mehmet, Verim Ayşegül, Süoğlu Yusufhan, Yaylım İlhan, Ergen Arzu

Abstract excerpt

INTRODUCTION: The most prevalent head and neck cancer type is laryngeal cancer. Laryngeal cancer susceptibility is increased by a combination of genetic variables and environmental factors. Genetic predispositions that influence the functioning of the immune system can affect tumor development. Our study investigates the impact of alterations in CD40 (rs1883832) and CD40L (rs1126535) genes and the levels of their...

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Identifiers

PMID: 39625893
DOI: 10.1371/journal.pone.0312576
PMCID: PMC11614260

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