Article
Association of CD40 gene polymorphisms with sporadic breast cancer in Chinese Han women of Northeast China.
PloS one - 1 Jan 2011
Shuang Chen, Dalin Li, Weiguang Yuan, Zhenkun Fu, Fengyan Xu, Da Pang, Li Dianjun
Abstract excerpt
BACKGROUND: Breast cancer is a polygenetic disorder with a complex inheritance pattern. Single nucleotide polymorphisms (SNPs), the most common genetic variations, influence not only phenotypic traits, but also interindividual predisposition to disease, treatment outcomes with drugs and disease prognosis. The co-stimulatory molecule CD40 plays a prominent role in immune regulation and homeostasis. Accumulating...
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