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Article

Impact of TLR4 and MYD88 Genetic Variants on Disease Progression and Prognosis in Laryngeal Squamous Cell Carcinoma.

International journal of molecular sciences - 25 May 2026

Mikulskienė Akvilė, Vadeikienė Roberta, Vegienė Aurelija, Ugenskienė Rasa, Juozaityte Elona, Padervinskis Evaldas

Abstract excerpt

Laryngeal cancer is a relatively uncommon malignancy with predisposing genetic factors that remain unclear. Single-nucleotide polymorphisms (SNPs) in genes involved in innate immune signaling may contribute to the development and progression of laryngeal carcinoma. This study aimed to evaluate the association of TLR4 (rs7037225, rs11536889, rs7037117) and MYD88 (rs7744, rs6853) polymorphisms with the risk of...

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Share to Aged
Share to Carcinoma, Squamous Cell
Share to Case-Control Studies
Share to Disease Progression
Share to Laryngeal Neoplasms
Share to Myeloid Differentiation Factor 88
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Share to Toll-Like Receptor 4

Source

Open in PubMed Open full text

Identifiers

PMID: 42278290
DOI: 10.3390/ijms27114760
PMCID: PMC13256836

Genes

MYD88
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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