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Genome-wide association study identifies risk loci within the major histocompatibility complex region for Hunner-type interstitial cystitis

1 Jul 2023

Abstract excerpt

Hunner-type interstitial cystitis (HIC) is a rare, chronic inflammatory disease of the urinary bladder with unknown etiology and genetic background. Here, we conduct a genome-wide association study of 144 patients with HIC and 41,516 controls of Japanese ancestry. The genetic variant, rs1794275, in the major histocompatibility complex (MHC) region (chromosome 6p21.3) is associated with HIC risk (odds ratio [OR] =...

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PMID: 37467720
DOI: 10.1016/j.xcrm.2023.101114

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