Article
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases.
Nature genetics - 1 Jul 2020
Ishigaki Kazuyoshi, Akiyama Masato, Kanai Masahiro, Takahashi Atsushi, Kawakami Eiryo, Sugishita Hiroki, Sakaue Saori, Matoba Nana, Low Siew-Kee, Okada Yukinori, Terao Chikashi, Amariuta Tiffany, Gazal Steven, Kochi Yuta, Horikoshi Momoko, Suzuki Ken, Ito Kaoru, Koyama Satoshi, Ozaki Kouichi, Niida Shumpei, Sakata Yasushi, Sakata Yasuhiko, Kohno Takashi, Shiraishi Kouya, Momozawa Yukihide, Hirata Makoto, Matsuda Koichi, Ikeda Masashi, Iwata Nakao, Ikegawa Shiro, Kou Ikuyo, Tanaka Toshihiro, Nakagawa Hidewaki, Suzuki Akari, Hirota Tomomitsu, Tamari Mayumi, Chayama Kazuaki, Miki Daiki, Mori Masaki, Nagayama Satoshi, Daigo Yataro, Miki Yoshio, Katagiri Toyomasa, Ogawa Osamu, Obara Wataru, Ito Hidemi, Yoshida Teruhiko, Imoto Issei, Takahashi Takashi, Tanikawa Chizu, Suzuki Takao, Sinozaki Nobuaki, Minami Shiro, Yamaguchi Hiroki, Asai Satoshi, Takahashi Yasuo, Yamaji Ken, Takahashi Kazuhisa, Fujioka Tomoaki, Takata Ryo, Yanai Hideki, Masumoto Akihide, Koretsune Yukihiro, Kutsumi Hiromu, Higashiyama Masahiko, Murayama Shigeo, Minegishi Naoko, Suzuki Kichiya, Tanno Kozo, Shimizu Atsushi, Yamaji Taiki, Iwasaki Motoki, Sawada Norie, Uemura Hirokazu, Tanaka Keitaro, Naito Mariko, Sasaki Makoto, Wakai Kenji, Tsugane Shoichiro, Yamamoto Masayuki, Yamamoto Kazuhiko, Murakami Yoshinori, Nakamura Yusuke, Raychaudhuri Soumya, Inazawa Johji, Yamauchi Toshimasa, Kadowaki Takashi, Kubo Michiaki, Kamatani Yoichiro
Abstract excerpt
The overwhelming majority of participants in current genetic studies are of European ancestry. To elucidate disease biology in the East Asian population, we conducted a genome-wide association study (GWAS) with 212,453 Japanese individuals across 42 diseases. We detected 320 independent signals in 276 loci for 27 diseases, with 25 novel loci (P < 9.58 × 10-9). East Asian-specific missense variants were identified...
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