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Article

Asialoglycoprotein receptor subunit Asgr1a loss results in attenuated cholesterol absorption in zebrafish fed a western diet.

The Journal of biological chemistry - 1 Aug 2026

Derrick Joshua T, Moll Tabea O C, Sweeney Darby W, Shin Jeffrey, Svecla Monika, Norata Giuseppe Danilo, Farber Steven A

Abstract excerpt

One of the major pathways to clear glycoproteins from circulation is via the liver-specific asialoglycoprotein receptor. Loss of asialoglycoprotein receptor 1 (ASGR1), the major subunit of asialoglycoprotein receptor in humans, was found to correlate with lower levels of plasma apolipoprotein B-containing lipoproteins and a profound reduction in cardiovascular disease risk. However, the cell and molecular biology...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42264088
DOI: 10.1016/j.jbc.2026.113239
PMCID: PMC13355650

Genes

ASGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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