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CRISPR/Cas: from adaptive immune system in prokaryotes to therapeutic weapon against immune-related diseases

18 Oct 2019

Abstract excerpt

CRISPR/Cas evolved as an adaptive immune system in bacteria and archaea to inactivate foreign viral and plasmid DNA. However, the capacities of various CRISPR/Cas systems for precise genome editing based on sequence homology also allow their use as tools for genomic and epigenomic modification in eukaryotes. Indeed, these genetic characteristics have proven useful for disease modeling and testing the specific...

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PMID: 31625429
DOI: 10.1080/08830185.2019.1677645

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