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Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

7 Feb 2018

Abstract excerpt

During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo spatially organized fate specification on micropatterned surfaces. Since in vivo validation is not possible for the human, we developed a mouse PSC micropattern system and, with direct comparisons to mouse embryos, reveal the robust...

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PMID: 29412136
DOI: 10.7554/elife.32839

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