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Genetic-by-age interaction analyses on complex traits in UK Biobank and their potential to identify effects on longitudinal trait change.

Genome biology - 28 Nov 2024

Winkler Thomas W, Wiegrebe Simon, Herold Janina M, Stark Klaus J, Küchenhoff Helmut, Heid Iris M

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) have identified thousands of loci for disease-related human traits in cross-sectional data. However, the impact of age on genetic effects is underacknowledged. Also, identifying genetic effects on longitudinal trait change has been hampered by small sample sizes for longitudinal data. Such effects on deteriorating trait levels over time or disease progression can...

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PMID: 39609904
DOI: 10.1186/s13059-024-03439-9
PMCID: PMC11606088

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APOE
FBN1
IGFBP3
TFAP2B
TMEM18

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