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Article

Mendelian Randomization of Blood Metabolites Suggests Circulating Glutamine Protects Against Late-Onset Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2024

Ramadan Ferris A, Arani Gayatri, Jafri Ayan, Thompson Tingting, Bland Victoria L, Renquist Benjamin, Raichlen David A, Alexander Gene E, Klimentidis Yann C

Abstract excerpt

Background: Late-onset Alzheimer's disease (LOAD) represents a growing health burden. Previous studies suggest that blood metabolite levels influence risk of LOAD. Objective: We used a genetics-based study design which may overcome limitations of other epidemiological studies to assess the influence of metabolite levels on LOAD risk. Methods: We applied Mendelian randomization (MR) to evaluate bi-directional...

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Identifiers

PMID: 38489176
DOI: 10.3233/JAD-231063
PMCID: PMC11805495

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