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Article

Endogenous chondroitin extends lifespan by inhibiting VHA-7-mediated tubular lysosome formation.

Scientific reports - 29 Nov 2024

Shibata Yukimasa, Tanaka Yuri, Mori Shunsuke, Mitsuzumi Kaito, Fujii Shion, Sasakura Hiroyuki, Morioka Yuki, Sugioka Kenji, Takeuchi Kosei, Nishiwaki Kiyoji

Abstract excerpt

Chondroitin extends lifespan and healthspan in C. elegans, but the relationship between extracellular chondroitin and intracellular anti-aging mechanisms is unknown. The basement membrane (BM) that contains chondroitin proteoglycans is anchored to cells via hemidesmosomes (HDs), and it accumulates damage with aging. In this study, we found that chondroitin regulates aging through the formation of HDs and...

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Identifiers

PMID: 39609482
DOI: 10.1038/s41598-024-80242-3
PMCID: PMC11605119

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