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Article

Loss of Chondroitin Sulfate Modification Causes Inflammation and Neurodegeneration in skt Mice.

Genetics - 1 Jan 2020

Macke Erica L, Henningsen Erika, Jessen Erik, Zumwalde Nicholas A, Landowski Michael, Western Daniel E, Lee Wei-Hua, Liu Che, Gruenke Nathan P, Doebley Anna-Lisa, Miller Samuel, Pattnaik Bikash, Ikeda Sakae, Gumperz Jenny E, Ikeda Akihiro

Abstract excerpt

One major aspect of the aging process is the onset of chronic, low-grade inflammation that is highly associated with age-related diseases. The molecular mechanisms that regulate these processes have not been fully elucidated. We have identified a spontaneous mutant mouse line, small with kinky tail (skt), that exhibits accelerated aging and age-related disease phenotypes including increased inflammation in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31754016
DOI: 10.1534/genetics.119.302834
PMCID: PMC6944401

Genes

CHSY1
CS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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