Article
Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.
Science (New York, N.Y.) - 19 Dec 2008
Sankaran Vijay G, Menne Tobias F, Xu Jian, Akie Thomas E, Lettre Guillaume, Van Handel Ben, Mikkola Hanna K A, Hirschhorn Joel N, Cantor Alan B, Orkin Stuart H
Abstract excerpt
Differences in the amount of fetal hemoglobin (HbF) that persists into adulthood affect the severity of sickle cell disease and the beta-thalassemia syndromes. Genetic association studies have identified sequence variants in the gene BCL11A that influence HbF levels. Here, we examine BCL11A as a potential regulator of HbF expression. The high-HbF BCL11A genotype is associated with reduced BCL11A expression....
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