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A proteogenomic atlas of idiopathic pulmonary arterial hypertension reveals sex-dimorphic mechanisms and potential novel therapeutic targets

2025-12-12

Abstract excerpt

<h4>Background: </h4> Current circulating biomarkers for idiopathic pulmonary arterial hypertension (IPAH) lack specificity for preclinical detection and fail to capture the biological heterogeneity driving disease progression. Furthermore, molecular mechanisms underlying the "sex paradox" of IPAH, where females exhibit higher susceptibility but lower mortality, remain poorly understood, hindering the development...

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Literature Corpus work
ea1b8f71-9d06-53e2-b0cc-a76ad25bf549
DOI
10.64898/2025.12.11.25341960
Open publication

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