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Article

Caenorhabditis elegans inositol hexaphosphate pathways couple to RNA interference and pathogen defense.

Proceedings of the National Academy of Sciences of the United States of America - 3 Dec 2024

Xu Wenjing, Sun Yifan, Breen Peter, Ruvkun Gary, Mao Kai

Abstract excerpt

RNA interference (RNAi) is an evolutionarily conserved pathway that defends against viral infections in diverse organisms. Caenorhabditis elegans mutations that enhance RNAi have revealed pathways that may regulate antiviral defense. A genetic screen for C. elegans mutations that fail to up-regulate a defense response reporter transgene detected mutations that enhance RNAi to silence this reporter gene in the...

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PMID: 39602251
DOI: 10.1073/pnas.2416982121
PMCID: PMC11626161

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ADAR

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