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Article

Disease severity in patients infected with Leishmania mexicana relates to IL-1β.

PLoS neglected tropical diseases - 1 Jan 2012

Fernández-Figueroa Edith A, Rangel-Escareño Claudia, Espinosa-Mateos Valeria, Carrillo-Sánchez Karol, Salaiza-Suazo Norma, Carrada-Figueroa Georgina, March-Mifsut Santiago, Becker Ingeborg

Abstract excerpt

Leishmania mexicana can cause both localized (LCL) and diffuse (DCL) cutaneous leishmaniasis, yet little is known about factors regulating disease severity in these patients. We analyzed if the disease was associated with single nucleotide polymorphisms (SNPs) in IL-1β (-511), CXCL8 (-251) and/or the inhibitor IL-1RA (+2018) in 58 Mexican mestizo patients with LCL, 6 with DCL and 123 control cases. Additionally,...

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Identifiers

PMID: 22629474
DOI: 10.1371/journal.pntd.0001533
PMCID: PMC3358333

Genes

CXCL8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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