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Article

Genome-wide cross-disease analyses highlight causality and shared biological pathways of type 2 diabetes with gastrointestinal disorders.

Communications biology - 27 May 2024

Adewuyi Emmanuel O, Porter Tenielle, O'Brien Eleanor K, Olaniru Oladapo, Verdile Giuseppe, Laws Simon M

Abstract excerpt

Studies suggest links between diabetes and gastrointestinal (GI) traits; however, their underlying biological mechanisms remain unclear. Here, we comprehensively assess the genetic relationship between type 2 diabetes (T2D) and GI disorders. Our study demonstrates a significant positive global genetic correlation of T2D with peptic ulcer disease (PUD), irritable bowel syndrome (IBS), gastritis-duodenitis,...

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Share to Diabetes Mellitus, Type 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genome-Wide Association Study

Share to Helicobacter pylori-related gastroenterology studies

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Source

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Identifiers

PMID: 38802514
DOI: 10.1038/s42003-024-06333-z
PMCID: PMC11130317

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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