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Article

Type 2 diabetes mellitus and liver diseases: a phenome-wide Mendelian randomization atlas and genome-wide genetic correlation study.

European journal of gastroenterology & hepatology - 1 Mar 2026

Ding Rong, Zhou Min, Guan Kaile, Xie Liyan, Zhang Yue, Chen Qi, Li Jiaqi, Shan Lei, Lu Huimin

Abstract excerpt

BACKGROUND: The causal relationship between type 2 diabetes mellitus (T2DM) and the various liver disease phenotypes remains uncertain. RESEARCH DESIGN AND METHODS: Our study provides a comprehensive causal atlas by assessing the causal roles of T2DM across 12 major liver conditions using summary data from genome-wide association studies. RESULTS: Our study indicated significant genetic correlations between T2DM...

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PMID: 41757613
DOI: 10.1097/MEG.0000000000003096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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