Influence of angiotensin II type 1 receptors and angiotensin-converting enzyme I/D gene polymorphisms on the progression of Chagas' heart disease in a Brazilian cohort: Impact of therapy on clinical outcomes.

doi:10.1371/journal.pntd.0012703

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Article

Influence of angiotensin II type 1 receptors and angiotensin-converting enzyme I/D gene polymorphisms on the progression of Chagas' heart disease in a Brazilian cohort: Impact of therapy on clinical outcomes.

PLoS neglected tropical diseases - 1 Nov 2024

Protásio da Silva Thayse do Espírito Santo, Alvarado-Arnez Lucia Elena, Batista Angelica Martins, Alves Silvia Marinho Martins, Melo Gloria, Carrazzone Cristina Veloso, Moraes Isabelle de Oliveira, Pacheco Antonio G, Sarteschi Camila, Moraes Milton Ozório, Oliveira Wilson, Lannes-Vieira Joseli

Abstract excerpt

Chagas disease (CD), a neglected tropical disease, is caused by infection by the protozoan Trypanosoma cruzi. One-third of CD patients develop cardiac disease (CARD), an inflammatory and fibrotic process that may progress to heart failure associated with reduced left ventricular ejection fraction (LVEF). The determinants of CD progression are still uncertain. In non-infectious conditions, the...

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PMID: 39591456
DOI: 10.1371/journal.pntd.0012703
PMCID: PMC11630595

Genes

ACE
AGTR1
TNF

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