Influence of Angiotensin-converting Enzyme Insertion/Deletion Gene Polymorphism in Progression of Chagas Heart Disease.

doi:10.1590/0037-8682-0488-2019

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Article

Influence of Angiotensin-converting Enzyme Insertion/Deletion Gene Polymorphism in Progression of Chagas Heart Disease.

Revista da Sociedade Brasileira de Medicina Tropical - 1 Jan 2020

Alves Silvia Marinho Martins, Alvarado-Arnês Lúcia Elena, Cavalcanti Maria da Glória Aureliano de Melo, Carrazzone Cristina de Fátima Velloso, Pacheco Antônio Guilherme Fonseca, Sarteschi Camila, Moraes Milton Ozorio, Oliveira Junior Wilson Alves de, Medeiros Carolina de Araújo, Pessoa Fernanda Gallinaro, Mady Charles, Lannes-Vieira Joseli, Ramires Felix José Alvarez

Abstract excerpt

INTRODUCTION: Chagas disease (CD) is a neglected disease caused by the parasite Trypanosoma cruzi. One-third of infected patients will develop the cardiac form, which may progress to heart failure (HF). However, the factors that determine disease progression remain unclear. Increased angiotensin II activity is a key player in the pathophysiology of HF. A functional polymorphism of the angiotensin-converting...

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PMID: 32638886
DOI: 10.1590/0037-8682-0488-2019
PMCID: PMC7341830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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