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Article

Association of caspase-1 polymorphisms with Chagas cardiomyopathy among individuals in Santa Cruz, Bolivia.

Revista da Sociedade Brasileira de Medicina Tropical - 1 Jan 2000

Fu Katherine Yih-Jia, Zamudio Roxana, Henderson-Frost Jo, Almuedo Alex, Steinberg Hannah, Clipman Steven Joseph, Duran Gustavo, Marcus Rachel, Crawford Thomas, Alyesh Daniel, Colanzi Rony, Flores Jorge, Gilman Robert Hugh, Bern Caryn

Abstract excerpt

INTRODUCTION:: Trypanosoma cruzi (Tc) infection is usually acquired in childhood in endemic areas, leading to Chagas disease, which progresses to Chagas cardiomyopathy in 20-30% of infected individuals over decades. The pathogenesis of Chagas cardiomyopathy involves the host inflammatory response to T. cruzi, in which upstream caspase-1 activation prompts the cascade of inflammatory chemokines/cytokines, cardiac...

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Identifiers

PMID: 28954073
DOI: 10.1590/0037-8682-0015-2017
PMCID: PMC8370021

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