Article
G2019S Mutation of Leucine-Rich Repeat Kinase 2 Is a Cause of Lewy Body Dementia in Patients With North African Ancestors.
Alzheimer disease and associated disorders - 1 Jan 2024
Segers Kurt, Benoit Florence, Levy Sophie, Martinet Valérie, Schulz Joachim G, Bertrand Frédéric, De Bourgoing Gabrielle, Tatillo Chiara, Praet Jean-Philippe, Vandernoot Isabelle, Desmyter Laurence, Peyrassol Xavier, Kehagias Pashalina, Smits Guillaume, Dumoulin Baptiste, Besse-Hammer Tatiana, Dachy Bernard, Surquin Murielle
Abstract excerpt
BACKGROUND: Mutations in the LRRK2 gene are the most common genetic cause of Parkinson disease but are believed to play no significant role in Lewy body disease (LBD). OBJECTIVES: As the frequency of G2019S LRRK2 mutation is extremely high in North African patients with Parkinson disease, we postulate that the high prevalence of LBD in North Africa might be due to the same mutation because LBD and Parkinson...
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