Article
LRRK2 variation and Parkinson's disease in African Americans.
Movement disorders : official journal of the Movement Disorder Society - 15 Sept 2010
Ross Owen A, Wilhoite Greggory J, Bacon Justin A, Soto-Ortolaza Alexandra, Kachergus Jennifer, Cobb Stephanie A, Puschmann Andreas, Vilariño-Güell Carles, Farrer Matthew J, Graff-Radford Neill, Meschia James F, Wszolek Zbigniew K
Abstract excerpt
The global impact of LRRK2 mutations is yet to be realized with a lack of studies in specific ethnic groups, including those of Asian and African descent. Herein, we investigated the frequency of common LRRK2 variants by complete exon sequencing in a series of publicly available African American Parkinson's disease patients. Our study identified three novel synonymous exonic variants and 13 known coding...
Topics
- Adult
- Black or African American
- Aged
- Alleles
- Exons
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Male
- Middle Aged