Article

Leucine rich repeat kinase 2 (LRRK2) gly2019ser mutation is absent in a second cohort of nigerian africans with parkinson disease

2018-07-06

Abstract excerpt

<h4>ABSTRACT</h4> To date the LRRK2 p.G2019S mutation remains the most common genetic cause of Parkinson disease (PD) worldwide. It accounts for up to 6% of familial and approximately 1.5% of sporadic cases. LRRK2 has a kinase enzymatic domain which provides an attractive potential target for drug therapies and LRRK2 kinase inhibitors are in development. Prevalence of the p.G2019S has a variable ethnic and geogra...

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Literature Corpus work: e2f84d11-9809-5555-b80d-47e0e4c1d579
DOI: 10.1101/363945

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