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Article

Genetic architecture of lumbar spinal stenosis.

Nature communications - 6 Apr 2026

Salo Ville, Määttä Juhani, Takala Jasmin, Heikkilä Anni, Reimann Ene, Mägi Reedik, Reis Kadri, Elhanas Abdelrahman G, Reigo Anu, Palta Priit, Esko Tõnu, Leinonen Ville, Karppinen Jaro, Sliz Eeva, Kettunen Johannes

Abstract excerpt

Lumbar spinal stenosis (LSS) affects over 100 million people globally, with an increasing incidence due to an ageing population. While LSS is known to be heritable, its genetic basis remains poorly understood. We conduct a genome-wide meta-analysis of LSS in 40,303 cases and 741,469 controls. We identify 73 previously unreported loci in addition to 15 known loci, and highlight spinal degeneration as a key...

Topics

Spinal Stenosis
Humans
Genome-Wide Association Study
Genetic Predisposition to Disease
Lumbar Vertebrae
Polymorphism, Single Nucleotide
Mendelian Randomization Analysis
Age of Onset
Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41942452
DOI: 10.1038/s41467-026-70935-w
PMCID: PMC13234025

Genes

LSS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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