Article
Modeling early phenotypes of Parkinson's disease by age-induced midbrain-striatum assembloids.
Communications biology - 23 Nov 2024
Barmpa Kyriaki, Saraiva Claudia, Lopez-Pigozzi Diego, Gomez-Giro Gemma, Gabassi Elisa, Spitz Sarah, Brandauer Konstanze, Rodriguez Gatica Juan E, Antony Paul, Robertson Graham, Sabahi-Kaviani Rahman, Bellapianta Alessandro, Papastefanaki Florentia, Luttge Regina, Kubitscheck Ulrich, Salti Ahmad, Ertl Peter, Bortolozzi Mario, Matsas Rebecca, Edenhofer Frank, Schwamborn Jens C
Abstract excerpt
Parkinson's disease, an aging-associated neurodegenerative disorder, is characterised by nigrostriatal pathway dysfunction caused by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. Human in vitro models are enabling the study of the dopaminergic neurons' loss, but not the dysregulation within the dopaminergic network in the nigrostriatal pathway. Additionally, these...
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